There is a “price to pay” for taking a weight-loss drug, according to those who helped develop it The seventies
A scientist whose work in the 1970s helped pioneer weight-loss drugs such as ozimbek Be warned that people will struggle to eat it for more than a few years because it takes away from the joy of eating. Professor Jens Juul Holst said in an interview with Wired.
Over the past few months, Semaglutide — sold under the brand names Ozempic and Wegovy, among others — has reached Dominate the cultural conversation Thanks to its off-label use as a Weight loss drug. Originally created to treat diabetes, the drug was found to regulate blood sugar levels, significantly suppressing one’s appetite and slowing the rate of stomach emptying. This means that it has become very popular among people looking to lose weight, and words like “miracle,” “revolutionary,” “silver bullet” and “holy grail” are thrown around when talking about the drug. According to some reports, there is mass use of the drug in Hollywood and Manhattan and it seems to be making its way now Westminster.
Holst, a professor in the Department of Biomedical Sciences at the University of Copenhagen, began researching GLP-1, the hunger-regulating hormone that mimics semaglutide, in the 1970s. It was his work developing therapies around GLP-1 that led directly to the creation of Semaglutide, though scientists were initially working on treatments for duodenal ulcer disease before realizing it had benefits for diabetics and then for weight loss and obesity.
Semaglutide is not without its side effects. Nausea, dizziness, constipation, vomiting and diarrhea often come as part of the package, while patients also report hair loss and facial thinning -”Ozempic face– as a result of rapid weight loss. Kidney failure, pancreatitis, and bowel obstruction may occur in rare cases. Besides, according to Professor Holst, there is a loss of joy when it comes to food. “What happens is you lose your appetite and also the pleasure of eating, and so I think there is a price to pay when you do that. If you love food, that pleasure goes away,” he warned.
But one’s appetite does not appear to be suppressed. Reports have emerged that people are also losing the will to do everything from drinking alcohol to smoking cigarettes to going shopping and biting their nails. Laboratory rats taking GLP-1 drugs are more able to say no for cocaine. in condition posted by Atlantic OceanOne woman’s experience taking semaglutide described as transforming her brain. “The desire to shop disappeared. The desire to drink, once extinguished, did not rush in as a substitute either. For the first time—perhaps for the first time in her whole life—all her desires and impulses vanished.”
This is likely to happen because GLP-1 drugs may alter the brain’s basic reward circuits – that is, they affect the dopamine pathways in the brain so that the same reward (whether it’s eating, sex, or other activities that normally triggers dopamine in the brain) ) brings less pleasure. Aside from anecdotal evidence, the majority of research on this relationship has been on animals, thus more human trials are needed, which may disprove the drug’s efficacy in addiction.
Another concern is that once you stop taking the medication, the effects are Often reversible When it comes to weight, it means the same will happen with addiction. “The weight comes back. The appetite suppression goes away,” said Dr. Janice Jin Huang Atlantic Ocean. And people don’t seem to take drugs. in 2020, Search found That 70 percent of patients on GLP-1 stopped taking it within two years.
“One of the reasons, like I said, is that once you try it and realize you’ve lost interest in food, that might be enough. We don’t know why people stop taking these drugs, but we do know for a fact that they stop,” Holst said. Wired. “I don’t see a significant portion of the population going to be put on Wegovy and stay on Wegovy for the rest of their lives — I simply don’t see that picture, because this hasn’t happened with other GLP-1 drugs.”
Even if a GLP-1 drug turns out to be effective in reducing all cravings and addiction, not everyone believes that a drug that suppresses cravings and frees you from them is a positive thing. “The idea of the Ozempic era, full of people paying a fortune to no longer be able to enjoy one of mankind’s greatest pleasures, is just incredibly depressing,” He writes Vanity Fair Editor Katey Rich.
Is there anything dystopian about a drug that drug people with pleasure and indulgence—especially in a culture that often Encourages strict self-discipline and oppression? Will he create a stoic society where people can biologically hack their bodies to maximize focus and efficiency, without the distraction that comes from having needs? An entire workforce designed to live like a robot without wanting food, drinks, sex, or any other kind of desire?
In Aldous Huxley’s dystopian tale 1932 Brave New WorldPleasure is a priority and is achieved through the mass deployment of Soma, a mood-altering drug that blocks negative emotions. The result is a community completely numbed by pure bliss. Will Ozempic deliver the opposite – numbness through desire suppression? Nutritionist Kristina Johnson says: Vice condition.
On the other hand, addiction destroys people, families And Communities – Stanford University estimated that 1.2 million people In the US and Canada they will die from opioid overdoses by the end of the decade – and if there was a drug that could help without the side effects of drugs like methadone, surely that could only be a good thing.
Without more research and time to study the long-term effects of drugs like Ozempic, it’s impossible to know what will happen. In the meantime, it pays to be wary of any drug that’s hailed as a miracle—especially when it comes to the weight-loss industry that has a long history of drugs that turn out to be too good to be true.
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